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31.
32.
目的 了解早期全身运动(GMs)评估结果为异常/可疑的非脑瘫早产儿与筛查正常的早产儿在婴幼儿期神经、认知等各方面整体发育水平的差异,以探索GMs评估与儿童轻微神经功能障碍的关系。方法 选取2009-2017年在上海市闵行区妇幼保健院扭动阶段或不安阶段至少进行过1次GMs评估的早产儿,于矫正后9、12、24月龄评估其智力指数(MI)、发育商(DQ)。结果 单因素分析显示,扭动阶段/不安阶段结果为异常/可疑的非脑瘫早产儿与正常结果相比,MI与DQ差异均无统计学意义(P>0.05);多因素分析显示,不安运动结果为异常/可疑与正常相比,发育异常结局的可能性大(9月龄:OR=3.075,95%CI:1.013~9.331;12月龄:OR=3.638,95%CI:1.552~8.527;24月龄:OR=2.750,95%CI:1.213~6.242);不安运动评估结果对不同年龄发育异常结局预测的灵敏度较低(8.82%~18.60%),特异度较高(>95%)。结论 GMs评估在预测婴幼儿后期神经、运动发育情况存在局限性,不可取代后续的各类发育评估与监测。 相似文献
33.
《Vaccine》2019,37(50):7295-7299
Gastric adenocarcinoma is globally the third leading cause of death due to malignancy, with the bulk of this disease burden being suffered by low and middle income countries (LMIC), especially in Asia. The majority of these cancers develop as a result of a chronic gastritis that arises in response to infection with the stomach-dwelling bacterium, Helicobacter pylori. A vaccine against this pathogen would therefore be a powerful tool for preventing gastric adenocarcinoma. However, notwithstanding a proof-of-concept that vaccination can protect children from acquisition of H. pylori infection, there are currently no advanced vaccine candidates with only a single vaccine in Phase I clinical trial. Further, the development of a vaccine against H. pylori is not a current strategic priority of major pharmaceutical companies despite the large global disease burden. Given the involvement of such companies is likely to be critical for late stage development, there is therefore a need for an increased appreciation of the burden of this disease in LMIC and more investment to reinvigorate research in H. pylori vaccine Research and Development. 相似文献
34.
《Vaccine》2019,37(34):4811-4813
Catalyzing and sustaining momentum for long-term research investments can be a challenge, especially for enteric pathogens like ETEC and Shigella that are most threatening to the health of children in low-resource areas, and whose vaccines would not be for global use. The 2018 Vaccines Against Shigella and ETEC (VASE) Conference included a workshop focused on building the capacity of scientists to communicate about their own research and advocate for additional attention and funding for enteric disease and vaccines research. Workshop presenters shared best practices and examples of advocacy, communications, and messaging tactics that have been used successfully during early stages of vaccine development research for other pathogens. The presentations were followed by an interactive, hands-on training for real-life communication opportunities for scientists that could result in increased research funding, including developing resonant messaging for relevant audiences and practicing interviews. 相似文献
35.
Objective
This study aims to assess the correlation between the exclusive breastfeeding status with infant's early language milestone.Method
The design of this study is the correlational study with cross sectional method. This study examined 57 infants who lived around Harapan Raya Community Health Center Pekanbaru. The age of the infants was 6 months old during the data collection. The breastfeeding status was examined by using the questionnaire. The infants early language development was assessed by using the questionnaire which was modified from ELM Scale 2 (Early Language Milestone Scale 2). The data was analyzed by using the chi square or Fisher exact test to assess the correlation of exclusive breastfeeding status with each milestone on the 6 months infants language development.Results
The study found that exclusive breastfeeding status has correlated significantly with two language milestones which are Auditory Expressive 6 (AE 6) the infant ability to produce mono babbling (0.044) and Auditory Receptive 6 (AR 6) the infant inhibit to ‘no’ (0.011).Conclusions
This study found that exclusive breastfeeding has a correlation in infant language milestone. However due to small sampling size, further study needed to be done to assess the effect of breastfeeding for infants with the bigger scale of population. 相似文献36.
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39.
本文立足于促进骨骼影像学的发展,在宏观分析骨骼影像学临床应用与研究现状的基础上,指出了存在的主要问题及原因,认为骨骼影像学的再进步,有赖于从大体形态学定性到微观成分定量的思路转变和具体技术研究的突破,以及学科内部专业整合、相关学科交叉、跨学科技术协作等的思路与发展方向。 相似文献
40.
目的探析苍附导痰汤治疗痰湿型多囊卵巢综合征的疗效。方法查阅文献并结合临床,对痰湿型多囊卵巢综合征的中西医病机及苍附导痰汤方药进行分析,探求方证关系,并附验案以示之。结果多囊卵巢综合征为中医学中“不孕症”“月经后期”“闭经”“癥瘕”等疾病的范畴,证型以痰湿阻滞型多见;苍附导痰汤是《叶天士女科诊治秘方》中的经典方,适用于痰湿型多囊卵巢综合征,本方用治痰湿型多囊卵巢综合征有其独特优势。结论苍附导痰汤治疗痰湿型多囊卵巢综合征值得临床推广。 相似文献